selective nrf2 inhibitor ml385  (MedChemExpress)

Journal: BMC Nephrology

Article Title: Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway

doi: 10.1186/s12882-025-03977-9

Figure Lengend Snippet: The effects of UDCA on the renal Nrf2/HO-1 signaling in LPS-induced AKI mice. ( A ) The immunoblot bands of Nrf2 and HO-1. ( B ) The relative expression of Nrf2 protein. ( C ) The relative expression of HO-1 protein. ( D ) The molecular docking of UDCA and Nrf2. Data were represented as mean ± S.E.M. # p < 0.05, ### p < 0.001 v.s . Control group; * p < 0.05, ** p < 0.01, and *** p < 0.001 v.s . LPS-vehicle group. n = 3

Article Snippet: ML385 (99.96%, No. HY-100523), a selective Nrf2 inhibitor, was obtained from MCE (Shanghai, China).

Techniques: Western Blot, Expressing, Control

Journal: BMC Nephrology

Article Title: Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway

doi: 10.1186/s12882-025-03977-9

Figure Lengend Snippet: The effects of Nrf2 inhibitor on the cell survival and apoptosis in HK2 cells treated with LPS. ( A ) Cell viability (Treated with 40 µM UDCA, 5 µg/mL LPS, and 10 µM ML385). ( B ) The apoptosis rate (40 µM UDCA, 5 µg/mL LPS, and 10 µM ML385). ( C ). Representative images of cell apoptosis detected using a flow cytometer. Data were represented as mean ± S.E.M. ### p < 0.001 v.s . Control group; ** p < 0.01, and *** p < 0.001 v.s . LPS-vehicle group. n = 6 for A; n = 3 for B-C

Article Snippet: ML385 (99.96%, No. HY-100523), a selective Nrf2 inhibitor, was obtained from MCE (Shanghai, China).

Techniques: Flow Cytometry, Control